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KMID : 0043319980210060729
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Archives of Pharmacal Research
1998 Volume.21 No. 6 p.729 ~ p.733
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Topoisomerase I Inhibitors from the Streptomyces sp. Strain KM86-9B Isolated from a Marine Sponge
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Lee Hong-Kum
Lee Deuk-Soo
Lim Jung-Hyun
Kim Jung-Sun
Im Kwang-Sik
Jung Jee H.
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Abstract
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The crude extract of Streptomyces sp. strain KM86-9B, isolated from a marine sponge, displayed significant inhibition on topoisomerase I activity. Investigation of the ca usative components by bioactivity-directed fractionation resulted in the isolation of a series of iso- and anteiso-fatty acids.
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KEYWORD
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Topoisomerase I inhibitor, Marine actionmycete, Isofatty acids, Anteiso-fatty acids, Marine sponge
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